Dictionary

zalcitabine en · NOUN

Pronunciation

• /zælˈsaɪ.təˌbin/ (General-American)
• /zælˈsɪt.əˌbin/ (General-American)
• /zalˈsɪt.ə.biːn/ (Received-Pronunciation)

Etymology

From [Term?] + -citabine (“cytarabine or azacytidine derivative”).

Meanings

1. (countable, uncountable) A drug C₉H₁₃N₃O₃ which inhibits the replication of HIV and is formerly used in the treatment of AIDS, especially in combination with zidovudine. It is a synthetic analog of a pyrimidine nucleoside, acting as a reverse transcriptase inhibitor.
   • Patients received 600 mg/day of ritonavir (Abbott Laboratories) for 14 days, after which were added 600 mg/day of zidovudine (Retrovir, Glaxo-Wellcome) and 6 mg/day of zalcitabine (Hivid, Roche) with treatment maintenance for 12 months. 1997 July 4, B. Autran et al., “Positive Effects of Combined Antiretroviral Therapy on CD4 T Cell Homeostasis and Function in Advanced HIV Disease”, in Science, volume 277, number 5322, →DOI, pages 112–116:

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