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Dictionary

Words, grammatical forms and meanings linked to the ontology.

thioguanosine en · NOUN

Etymology

From thio- + guanosine.

Meanings

  1. (uncountable) The compound 2-amino-6-mercapto-9-(b-D-ribofuranosyl)purine formally derived from guanosine by replacing the guanine by thioguanine
    • Several drug classes which are listed top on the list include topoisomerase inhibitors (camptothecin, ellipticine, doxorubicin, etoposide, thioguanine, thioguanosine), multiple histone deacetylase inhibitors (trichostatin A, vorinostat, 5162773, 5186223), PARP inhibitors (1,5-isoquinolinediol, 3-aminobenzamide, phenanthridinone), proteasome inhibitors (MG132, 1,4 chrysenequinone) and cyclin-dependent kinases (CDKs) inhibitors (alsterpaullone, 02974170002B, GW-8510). 2016 March 4, “PI-3K Inhibitors Preferentially Target CD15+ Cancer Stem Cell Population in SHH Driven Medulloblastoma”, in PLOS ONE, →DOI: