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Words, grammatical forms and meanings linked to the ontology.

tacrine en · NOUN

Pronunciation

  • /ˈtæ.kɹiːn/

Etymology

From t(etrahydro) + acr(id)ine.

Meanings

  1. (uncountable) A synthetic drug used in Alzheimer's disease to inhibit the breakdown of acetylcholine by cholinesterase and thereby enhance neurological function.
    • In the 1980s, Dr. Thal, a neurologist, helped lead successful clinical trials of tacrine, a cholinesterase inhibitor drug that was approved by the Food and Drug Administration in 1993. 2007 February 8, Jeremy Pearce, “Leon J. Thal, Neurologist Who Led Study for Alzheimer’s Drugs, Dies at 62”, in New York Times: