supersensitivity en · NOUN
Pronunciation
- (US) audio
- /ˌsuːpəɹ.sɛnsəˈtɪvətiː/
Etymology
From super- + sensitivity.
Meanings
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(uncountable) Extreme sensitivity (of the body) to a chemical.
Because D 1 dopamine receptors are known to act through stimulatory heterotrimeric guanosine triphosphate-binding (G s ) proteins and activation of the cAMP pathway, up-regulation of this pathway in the nucleus accumbens could account for the functional supersensitivity of D 1 receptors observed in these neurons--which occurs in the absence of detectable changes in the receptors themselves--after chronic cocaine (or other stimulant) exposure (18 ).
1997 October 3, Eric J. Nestler, George K. Aghajanian, “Molecular and Cellular Basis of Addiction”, in Science, volume 278, number 5335, →DOI, pages 58–63:The effects of inactivity on new receptor synthesis and denervation supersensitivity are mediated by Ca 2 influx (24 ).
1999 October 15, Mohammed Akaaboune et al., “Rapid and Reversible Effects of Activity on Acetylcholine Receptor Density at the Neuromuscular Junction in Vivo”, in Science, volume 286, number 5439, →DOI, pages 503–507:In the next generation seeds were screened for ABA supersensitivity (era1/era1).
1998 October 9, Zhen-Ming Pei et al., “Role of Farnesyltransferase in ABA Regulation of Guard Cell Anion Channels and Plant Water Loss”, in Science, volume 282, number 5387, →DOI, pages 287–290: