In trouble or in difficulty. (Compare in the soup.)
Luck I had the presenee [sic] of mind to dive into Manning's or I was souped. 1922, James Joyce, Ulysses, section II:
(slang) Intoxicated, drunk.
[…] souped to the gills. He had been drinking with his buddies while momma lay in a hospital bed. He was face down on the floor laughing and singing. 2012 08, Tammy Tucker, The River Bottoms, Xlibris Corporation, →ISBN, page 166:
'There's always morphine,' he said, and I imagined myself, in a bed crisp as blank paper, tubes up my nose and in my arms, souped to the eyeballs on morphine and trying to tell my friends what I thought of them. 2018, Cate Kennedy, Dark Roots, Open Road + Grove/Atlantic, →ISBN, page 26: