Dictionary
Words, grammatical forms and meanings linked to the ontology.
second puberty en · NOUN
Meanings
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(slang, uncountable) The physical, hormonal, and emotional changes that occur in adulthood.
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(uncountable) The physical, hormonal, and emotional changes that occur during a hormone replacement therapy.
During gender-affirming hormone therapy, you will go through what is called a “second puberty.” This means that the same emotional struggles that your first puberty may have brought — mood swings, anxiety and depression — are possibilities as an adult during your second puberty.
2024 October 25, Helene Frances Hedian, M.D., “Gender-Affirming Hormone Therapy (GAHT)”, in John Hopkins Medicine, archived from the original on 22 Aug 2025: