prehepatic en · ADJ
Etymology
From pre- + hepatic.
Meanings
- (not-comparable) anterior to the liver.
-
(not-comparable) upstream of the liver in the circulation of the hepatic portal system; and thus, before the metabolic effect of the liver.
Administration of intravenous edoxaban with and without rifampin may have differentiated the prehepatic versus hepatic effects of rifampin on parent and metabolite exposure.
2015 June 12, Jeanne Mendell et al., “The Effect of Rifampin on the Pharmacokinetics of Edoxaban in Healthy Adults”, in Clinical Drug Investigation, volume 35, →DOI: