Dictionary

patch clamp en · NOUN

Meanings

1. A device used to measure the ion currents in individual living cells.
   • The effect of cenobamate on various human sodium channels (Naᵥ1.1‐Naᵥ1.8) was characterized using automated patch clamp on stably expressing cells (n = 3–4). 2025 Oct, William J Crumb Jr, Susan M Melnick, Kelli J Glenn, “The Cardiac Sodium Channel Safety Profile of Cenobamate at Therapeutic Concentrations: In Vitro Analyses”, in Clin Transl Sci, volume 18, number 10, →DOI, →PMID, →PMCID:
   • We have shown that the extracellular patch clamp can be reliably used to detect extremely small currents flowing through biological membranes. 1978 July, Erwin Neher, Bert Sakmann, Joe Henry Steinbach, “The Extracellular Patch Clamp: A Method for Resolving Currents through Individual Open Channels in Biological Membranes”, in Pflügers Archiv, volume 375, →DOI:

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