Dictionary

mismethylate en · VERB

Etymology

From mis- + methylate.

Meanings

1. To methylate incorrectly.
   • M. jannaschii Nep mismethylates T-arm resembling RNAs. 2012, Jan Philip Wurm, Marco Griese, Ute Bahr, Martin Held, Alexander Heckel, Michael Karas, Jörg Soppa, Jens Wöhnert, “Identification of the enzyme responsible for N1-methylation of pseudouridine 54 in archaeal tRNAs”, in RNA:
   • We did find that one of tbe Salmonella genes, cbiF, was capable of 'mismethylating' precorrin-3 at the 1 l-position, ie out of the natural order, to yield a tetramethyl pyrrocorphin 1994, A. Ian Scott, “The discovery of nature's pathway to vitamin B12. A 25 year Odyssey”, in Tetrahedron, volume 50, number 47:
   • Biosynthesis of Mismethylated Analogs of Cobalamin 2015, Robert A. Meyers, Synthetic Biology, page 412:
   • CysG is a homodimer with a subunit Mᵣ of 50,000, which, in addition to catalyzing methylation at C-2 and C-7, can also mismethylate precorrin 2 at C-12 to afford a trimethylpyrrocorphin derailment product. 2012, Karl Kadish, Kevin M. Smith, Roger Guilard, The Porphyrin Handbook, page 217:

Forms