Dictionary
Words, grammatical forms and meanings linked to the ontology.
misfold en · NOUN
Pronunciation
- (Southern-England) audio
- (Southern-England) audio
- /ˈmɪsfoʊld/
Etymology
Etymology tree
Proto-Indo-European *mey-?
Proto-Indo-European *meyth₂-der.
Proto-Germanic *missaz
Proto-Germanic *missa-
Proto-West Germanic *missa-
Old English mis-
Middle English mys-
English mis-
English fold
English misfold
From mis- + fold.
Meanings
-
An incorrect or abnormal folding.
Forms
misfold en · VERB
Pronunciation
- (Southern-England) audio
- /mɪsˈfoʊld/
- (Southern-England) audio
Etymology
Etymology tree
Proto-Indo-European *mey-?
Proto-Indo-European *meyth₂-der.
Proto-Germanic *missaz
Proto-Germanic *missa-
Proto-West Germanic *missa-
Old English mis-
Middle English mys-
English mis-
English fold
English misfold
From mis- + fold.
Meanings
-
(intransitive, of a protein or nucleic acid) To fold into an unusual or incorrect tertiary structure; misfolded proteins occur in various diseases, including amyloidoses and dementias, although the question of causation versus consequence is not yet definitively answered for dementias.
The prionopathies are best known among the neurodegenerative diseases for their ability to misfold, self-propagate, and infect other organisms.
2021 March 1, Anderson, K.N.; Overcast, W.B.; Brosch, J.R.; Graner, B.D.; Veronesi, M.C., “Prionopathies and Prionlike Protein Aberrations in Neurodegenerative Diseases”, in American Society of Neuroradiology, volume 11, number 2, →DOI, pages 127-148:
Forms