Dictionary

misdifferentiate en · VERB

Etymology

Etymology tree Proto-Indo-European *mey-? Proto-Indo-European *meyth₂-der. Proto-Germanic *missaz Proto-Germanic *missa- Proto-West Germanic *missa- Old English mis- Middle English mys- English mis- Proto-Indo-European *dwóh₁ ▲ Proto-Indo-European *trísinflu. Proto-Indo-European *d(w)is- Proto-Italic *dis- Latin dis- Proto-Indo-European *bʰer- Proto-Indo-European *-eti Proto-Indo-European *bʰéreti Proto-Italic *ferō Latin ferō Latin differō Latin differēns Proto-Indo-European *-(i)yós Proto-Italic *-ijos Proto-Italic *-ios Old Latin -ios Latin -ius Latin -ia Latin differentia New Latin differentiō New Latin differentiātusbor. English differentiate English misdifferentiate From mis- + differentiate.

Meanings

1. To fail to differentiate correctly.
   • Sumoylation-deficient Drosophila lesswright mutants have been shown to induce overproduction of hemocytes and form melanotic tumors whereas Ubc9 mutations activate progenitors to misdifferentiate, become hyperplastic, and develop microtumors [172, 173]. 2013, Theodoulakis Christofi, Yiorgos Apidianakis, “Drosophila and the Hallmarks of Cancer”, in Andreas Vilcinskas, editor, Yellow Biotechnology I: Insect Biotechnologie in Drug Discovery and Preclinical Research, page 100:
   • Mesenchymal stem cells of patients with ossification are thought to misdifferentiate into osteoblasts instead of target ligament cells because they have high osteogenic ability. 2020, Ken-Ichi Furakawa, Shunfu Chin, Toru Asari, Kanichiro Wada, Gentaro Kumagai, Yasuyuki Ishibashi, “Ectopic Ossification of Human Spinal Ligaments Caused by Mesenchymal Stem Cell Abnormalities”, in Atsushi Okawa, Morio Matsumoto, Motoki Iwasaki, editors, OPLL: Ossification of the Posterior Longitudinal Ligament, page 47:
   • In the absence of Mxxl, cranial neural crest-derived mesenchyme consequently fails to proliferate and misdifferentiates (Han et al., 2003a). 2008, Charles J. Epstein, Robert P. Erickson, Anthony Joseph Wynshaw-Boris, Inborn Errors of Development, page 705:

Forms