Dictionary

minicolumnopathy en · NOUN

Etymology

From minicolumn + -o- + -pathy.

Meanings

1. An atypical presentation of minicolumns within the human brain.
   • The initial results suggesting a minicolumnopathy in autism have been reproduced in two independent samples. 2014, Manuel F. Casanova, “The Neuropathology of Autism”, in Fred R. Volkmar, Kevin A. Pelphrey, Rhea Paul, Sally J. Rogers, editors, Handbook of Autism and Pervasive Developmental Disorders, Volume 1: Diagnosis, Development, and Brain Mechanisms, page 518:
   • The analysis of the current state of research in this area is guided by theoretical concepts developed in our laboratory, namely the neurodevelopmental “minicolumnopathy” hypothesis of autism that predicts an abnormal E/I ratio, GABA deficits, and gamma oscillation abnormality in autism (Casanova et al., 2002, 2003, 2015, 2015). 2020, Estate M. Sokhadze et al., “Psychological Markers of Arousal and Anxiety in Children with Autism Spectrum Disorder”, in Jane Johnson, Stephen M. Edelson, editors, Understanding and Treating Anxiety in Autism: A Multi-Disciplinary Approach, page 39:
   • Brain size is therefore not a confound to the reported minicolumnopathy of autistic patients. 2007, Juan Martos Pérez, New Developments in Autism: The Future is Today, page 282:

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