Dictionary

dicyclohexylcarbodiimide en · NOUN

Pronunciation

• /ˌdaɪˌsaɪkloʊˈhɛksəlˌkɑːrboʊdaɪˈɪmaɪd/

Etymology

From di- + cyclo- + hexyl + carbodiimide

Meanings

1. (countable, uncountable) A chemical reagent commonly used in organic synthesis to activate carboxylic acids so they can form bonds with amines, especially to create amide bonds in peptide synthesis. It works as a coupling agent that helps join molecules together, producing dicyclohexylurea as a byproduct.
   • The reaction was initiated by adding a solution containing 50 mmol/L potassium phosphate (pH 7.0), 5 mmol/L MgSO 4 and carbonyl cyanide m -chlorophenylhydrazone (CCCP, final 20 μ mol/L) or dicyclohexylcarbodiimide (DCCD, final 50 μ mol/L), and [ 3 H] l -alanine (38 Ci mmol −1, Moravek Biochemical, Brea, CA, USA; final, 0.54 μ mol/L). 2015 June 13, Seryoung Kim et al., “Characterization of the l-alanine exporter AlaE of Escherichia coli and its potential role in protecting cells from a toxic-level accumulation of l-alanine and its derivatives”, in MicrobiologyOpen, volume 4, →DOI:

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