Dictionary

citrullinate en · VERB

Etymology

From citrulline + -ate (verb-forming suffix).

Meanings

1. (transitive) To react with, or convert to, citrulline.
   • PADs do not typically citrullinate total arginines found in the amino acid sequence of a protein, but certain arginines are more susceptible to citrullination.[…]Likewise, PAD2 also citrullinates actin and myelin basic protein in the CNS, while PAD4 can citrullinate substrates like nucleophosmin, nuclear lamin C, and p21 (Lamensa and Moscarello 1993; Hagiwara et al. 2002; Tanikawa et al. 2012; Li et al. 2008). 2017, E. E. Witalison, L. J. Hofseth, “22: Citrullination in Inflammatory-Driven Carcinogenesis of the Colon”, in Anthony P. Nicholas, Sanjoy K. Bhattacharya, Paul R. Thompson, editors, Protein Deimination in Human Health and Disease, 2nd edition, Springer, page 433:
   • Furthermore, PPAD in contrast to human PAD is capable of citrullinating C-terminal arginine residues, which are generated by another Pg.-derived enzyme, arginine specific gingipain (Rgp) protease (81). 2020, Burkhard Möller, Florian Kollert, Anton Sculean, Peter M. Villiger, “79: Infectious Trigger in Periodontitis and the Gut in Rheumatoid Arthritis (RA)”, in Erminia Mariani, Mariagrazia Uguccioni, Daniela Frasca, editors, Immunobiology of Osteoarticular Diseases, Frontiers Media, page 83:
   • It has been shown that PPAD is able to citrullinate bacterial as well as host peptides such as fibrinogen and α-enolase. 2015 August 29, Stefan Reichert et al., “Association of levels of antibodies against citrullinated cyclic peptides and citrullinated α-enolase in chronic and aggressive periodontitis as a risk factor of Rheumatoid arthritis: a case control study”, in Journal of Translational Medicine, volume 13, →DOI:

Forms

Deriveds

hypercitrullinate