Dictionary

autoimmunity en · NOUN

Pronunciation

• /ˌɔːtoʊɪˈmjuːnɪti/ (General-American)
• [ˌɑɾoʊɪˈmjunɪɾi] (cot-caught-merger)
• /ˌɔː.təʊ.ɪˈmjuː.nɪ.ti/ (Received-Pronunciation)
• /ˌɑtoʊɪˈmjuːnɪti/ (cot-caught-merger)
• (US) audio

Etymology

Etymology tree Proto-Indo-European *h₂ew Proto-Indo-European *tó- Proto-Hellenic *autós Proto-Indo-European *h₂ewder. Ancient Greek αὖ (aû) Ancient Greek τόν (tón) Ancient Greek αὐτός (autós) Ancient Greek αὐτο- (auto-)lbor. English auto- English immunity English autoimmunity From auto- + immunity.

Meanings

1. (countable, uncountable) The condition where one's immune system attacks one's own tissues, i.e., an autoimmune disorder.
   • This can be demonstrated in NOD mice in which a point mutation in the autoimmune regulator (Aire) gene results in the reduced expression of P0 in the thymus and a concomitant increase of P0 specific T cells in the periphery. 107 Similarly, autoimmunity is shifted towards the peripheral nerve in another NOD model deficient for isoforms of ICAM-1. 108 Altered expression of ICAM-1 on thymic epithelial cells transforms selection of T cells from a diabetogenic into a neuritogenic repertoire. 108 Studies such as these highlight the critical role of regulatory mechanisms in maintaining immune homeostasis and the impact that changes to regulation can have on the development of disease. 2015 February 12, Emily K Mathey et al., “Chronic inflammatory demyelinating polyradiculoneuropathy: from pathology to phenotype”, in Journal of Neurology, Neurosurgery, and Psychiatry, volume 86, →DOI:
   • Iberdomide, a cereblon modulator promoting degradation of the transcription factors Ikaros and Aiolos, which affect leukocyte development and autoimmunity, is being evaluated for the treatment of systemic lupus erythematosus (SLE). 2022 March 17, Joan T. Merrill, Victoria P. Werth, Richard Furie et al., “Phase 2 Trial of Iberdomide in Systemic Lupus Erythematosus”, in The New England Journal of Medicine, volume 386, number 11, →DOI, page 1034:

Forms

Deriveds

polyautoimmunity

Translations (17)

es autoinmunidad (condition where the immune system attacks the body's own tissues) · gl autoinmunidade (condition where the immune system attacks the body's own tissues) · ru аутоиммунность (condition where the immune system attacks the body's own tissues) · it autoimmunità (condition where the immune system attacks the body's own tissues) · sk autoimunita (condition where the immune system attacks the body's own tissues) · fo sjálvórin (condition where the immune system attacks the body's own tissues) · nl auto-immuniteit (condition where the immune system attacks the body's own tissues) · hu autoimmunitás (condition where the immune system attacks the body's own tissues) · pt autoimunidade (condition where the immune system attacks the body's own tissues) · ja 自己免疫 (condition where the immune system attacks the body's own tissues) · cs autoimunita (condition where the immune system attacks the body's own tissues) · ca autoimmunitat (condition where the immune system attacks the body's own tissues) · fi autoimmuniteetti (condition where the immune system attacks the body's own tissues) · ro autoimunitate (condition where the immune system attacks the body's own tissues) · cmn 自身免疫疾病 (condition where the immune system attacks the body's own tissues) · ko 자가 면역 (condition where the immune system attacks the body's own tissues) · de Autoimmunität (condition where the immune system attacks the body's own tissues)