Alprazolam is a central nervous system depressant. Avoid alcohol, other tranquilizers, narcotics, barbiturates, monoamine oxidase (MAO) inhibitors, antihistamines, and medicine used to relieve depression. 1990, Harold M. Silverman, Gilbert I. Simon, edited by Lawrence D. Chilnick, The Pill Book […] , 4th edition, New York: Bantam Books, →ISBN, page 39: