Dictionary

JAKinib en · NOUN

Etymology

From JAK (“Janus kinase”) + -in- + -ib (“small molecule inhibitor”).

Meanings

1. A Janus kinase inhibitor.
   • Blocking the JAK-STAT pathway with the Janus kinase inhibitor (JAKinib) baricitinib or tofacitinib reduces the expression of IFN-regulated genes (IRGs) in TNF-activated FLSs. […] The IFN-signature might be a promising biomarker for the efficient and personalized use of new treatment strategies for RA, such as JAKinibs. 2019 July 8, Michael Bonelli, Karolina Dalwigk, Alexander Platzer, Isabel Olmos Calvo, Silvia Hayer, Birgit Niederreiter, et al., “IRF1 is critical for the TNF-driven interferon response in rheumatoid fibroblast-like synoviocytes”, in Experimental & Molecular Medicine, volume 51, →DOI, page 1:

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