CBT-I en · NOUN Meanings (abbreviation, alt-of, initialism, uncountable) Initialism of cognitive behavioral therapy for insomnia. alt of cognitive behavioral therapy for insomnia When insomnia hits, she uses CBT-I – a form of cognitive behavioural therapy targeted to insomnia – as a remedy. 2023 March 26, Dr Ginni Mansberg, “‘Excellent evidence that this works’: how mind experts protect their brains”, in The Guardian, →ISSN: Relateds CBT